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 Formulary Chapter 2: Cardiovascular system - Full Chapter
Notes:
HDFT Guidelines on the management of stroke

Guidelines for the Management of Hyperglycaemia in Acute Coronary Syndrome (ACS)
Chapter Links...
 Details...
02.01  Positive inotropic drugs
02.01.01  Cardiac glycosides
Digoxin
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Formulary
Green
 
   
02.01.01  Digoxin-specific antibody
Digibind
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Formulary
Red
 
   
02.01.02  Phosphodiesterase type-3 inhibitors
02.02  Diuretics to top
02.02.01  Thiazides and related diuretics
Chlortalidone
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Formulary
Amber
 
   
Indapamide
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Formulary  
   
Xipamide (Diurexan®)
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Formulary
Amber
 
   
Metolazone (Unlicensed)
View adult BNF  Track Changes
Restricted Drug Restricted
Red
 
   
02.02.02  Loop diuretics
Furosemide
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Formulary
Green
Long-term supply problem with furosemide 500mg - switch to bumetanide 
   
Bumetanide
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Formulary
Green
 
   
02.02.03  Potassium-sparing diuretics and aldosterone antagonists
Amiloride Hydrochloride
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Formulary
Green
 
   
02.02.03  Aldosterone antagonists
Spironolactone
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Formulary
Green
 
   
Eplerenone (Inspra®)
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Restricted Drug Restricted
Amber
Initiation by Cardiology specialists only.

Patients to be switched to spironolactone 25mg daily by GP after 28 days of treatment with eplerenone.

 
   
02.02.04  Potassium-sparing diuretics with other diuretics to top
Co-amilofruse (furosemide and amiloride)
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Formulary
Green
Tablets amiloride/furosemide 2.5/20mg, 5/40mg 
   
Burinex A®
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Formulary
Green
Tablets amiloride/bumetanide 5/1mg 
   
02.02.05  Osmotic diuretics
Mannitol
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Formulary
Red
Infusion 10% 20% 
   
02.02.06  Mercurial diuretics
02.02.07  Carbonic anhydrase inhibitors
02.02.08  Diuretics with potassium
02.03  Anti-arrhythmic drugs to top
02.03.01  Management of arrhythmias
02.03.02  Drugs for arrhythmias
02.03.02  Supraventricular arrhythmias
Adenosine (Adenocor®)
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Formulary
Red
Injection 6mg/2ml 
   
Dronedarone (Multaq®)
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Restricted Drug Restricted
Amber Shared Care
For use by Cardiology Specialists only if intolerant to amiodarone 
Link  Dronedarone Shared Care Guidelines - HDFT
   
02.03.02  Supraventricular and ventricular arrhythmias
Amiodarone Hydrochloride
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Formulary
Amber
Tablets 100mg 200mg; Injection 150mg/3ml; Minijet 300mg/10ml 
Link  Amiodarone Shared Care Guidelines
   
Flecainide Acetate
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Formulary
Amber
Tablets 100mg; Injection 150mg/5ml (hospital only) 
   
Disopyramide
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Formulary
Amber
MR Tablets 250mg; Capsules 100mg;
Injection 50mg/5ml (hospital only) 
   
02.03.02  Ventricular arrhythmias to top
Lidocaine Hydrochloride (Minijet® Lignocaine)
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Formulary
Red
100mg/5ml 
   
Lidocaine Hydrochloride
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Formulary
Red
Infusion 0.1%, 0.2% in glucose 5% 
   
02.04  Beta-adrenoceptor blocking drugs
Atenolol
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Formulary
Green
Tablets 25mg, 50mg, 100mg; Liquid 25mg/5ml; Injection 5mg/10ml 
   
Bisoprolol Fumarate
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Formulary
Green
Tablets 1.25mg, 2.5mg, 5mg
First line in heart failure 
   
Carvedilol
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Restricted Drug Restricted
Green
Tablets 3.125mg, 6.25mg, 12.5mg
For Consultant use only
Second line in heart failure 
   
Esmolol Hydrochloride (Brevibloc®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
Injection 10mg/ml 
   
Labetalol Hydrochloride
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Formulary
Green
Tablets 100mg, 200mg;
Injection 100mg/20ml (hospital only) 
Link  Accelerated Hypertension Guidelines
Link  BP Management Protocol following Acute Haemorrhagic Stroke
Link  BP Management Protocol to lower BP prior to IV Thrombolysis for Acute Ischaemic Stroke
   
Metoprolol Tartrate
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Formulary
Green
Tablets 50mg 
Link  Accelerated Hypertension Guidelines
Link  IV metoprolol guidelines for supraventricular tachycardia
   
Nebivolol (Nebilet®)
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Restricted Drug Restricted
Amber
Cardiology initiation only 
   
Propranolol Hydrochloride
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Formulary
Green
 
   
Propranolol Hydrochloride (Half-Inderal® LA)
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Formulary
Green
MR Capsules 80mg 
   
Propranolol Hydrochloride (Inderal® LA)
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Formulary
Green
MR Capsules 160mg 
   
Sotalol Hydrochloride
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Formulary
Amber
Tablets 40mg, 80mg 
   
02.05  Drugs affecting the renin-angiotensin system and some other antihypertensive drugs
02.05.01  Vasodilator antihypertensive drugs
Hydralazine Hydrochloride
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Formulary
Red
Injection 20mg 
   
02.05.02  Centrally acting antihypertensive drugs
Moxonidine
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Restricted Drug Restricted
Amber
Tablets 200micrograms
For use by a specialist only 
   
02.05.03  Adrenergic neurone blocking drugs to top
02.05.04  Alpha-adrenoceptor blocking drugs
Doxazosin
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Formulary
Green
Tablets 1mg, 2mg, 4mg 
   
02.05.04  Phaeochromocytoma
02.05.05  Drugs affecting the renin-angiotensin system
02.05.05  Heart Failure
Valsartan (Diovan®)
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Formulary
Green
Tablets 40mg; Capsules 80mg, 160mg

For heart failure post myocardial infarction only 
   
02.05.05.01  Angiotensin-converting enzyme inhibitors (ACE inhibitors) to top
Ramipril
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First Choice
Green
Capsules 2.5mg 5mg 10mg 
Lisinopril
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Formulary
Green
Tablets 2.5mg 5mg 10mg 20mg 
   
Perindopril erbutine
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Formulary
Green
Tablets 2mg 4mg
For use by specialists in stroke patients only
Perindopril Erbutine only 
   
02.05.05.02  Angiotensin-II receptor antagonists
Losartan Potasium (Cozaar®)
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First Choice
Green
Tablets 25mg, 50mg 
Candesartan Cilexetil (Amias®)
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Restricted Drug Restricted
Green
Tablets 4mg 8mg 16mg 
   
Irbesartan (Aprovel ®)
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Restricted Drug Restricted
Green
Tablets 75mg 150mg
For use by specilaists only for diabetic nephropathy 
   
Sacubitril/valsartan  (Entresto®)
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Formulary
Amber
To be prescribed in line with NICE TA388 
Link  TA 388: Sacubitril valsartan for treating symptomatic chronic heart failure with reduced ejection fraction
   
02.05.05.03  Renin inhibitors
Aliskiren (Rasilez®)
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Restricted Drug Restricted
Amber
Tablets 150mg
For use by Renal Unit patients or on the advice of a specialist only 
   
02.06  Nitrates, calcium-channel blockers, and potassium-channel activators
02.06  Angina
Trimetazidine (Unlicensed)
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Restricted Drug Restricted MR Tablets 35mg

For use by specialists as last line therapy for unstable angina 
   
02.06.01  to top
 note 


Glyceryl Trinitrate
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Formulary
Green
Spray 400micrograms/dose; Buccal tablets 2mg, 3mg, 5mg; Sublingual tablets 500micrograms; Injection 50mg/50ml (hospital only) 
Link  BP Management Protocol following Acute Haemorrhagic Stroke
Link  BP Management Protocol to lower BP prior to IV Thrombolysis for Acute Ischaemic Stroke
   
Isosorbide Mononitrate
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Formulary
Green
  • Consider isosorbide mononitrate as monotherapy for stable angina if beta blockers and calcium channel blockers cannot be tolerated or both are contraindicated.
  • Consider adding isosorbide mononitrate if symptoms of stable angina are not controlled with beta blocker or calcium channel blocker monotherapy and the other option (calcium channel blocker or beta blocker) is contraindicated or not tolerated.

See NICE CG126: stable angina

 
Link  NICE CG126: Stable angina
Link  Use of Nitrates in Stable Angina
   
Isosorbide Dinitrate
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
Injection 10mg/10ml
For use in Cardiac Unit only 
   
02.06.02  Calcium-channel blockers
Amlodipine
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First Choice
Green
Tablets 5mg, 10mg 
Diltiazem Hydrochloride (Tildiem®)
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Formulary
Green
MR tablets (SR) 60mg, 90mg, 120mg
(twice daily dosing)

MR capsules (LA) 200mg, 300mg
(once daily dosing)

Prescribe by brand 
   
Diltiazem Hydrochloride (Adizem®)
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Formulary
Green
SR Capsules 90mg, 120mg, 180mg
(twice daily dosing)

XL Capsules 120mg, 180mg, 240mg, 300mg
(once daily dosing)

Prescribe by brand 
   
Diltiazem Hydrochloride (Adizem-SR®)
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Formulary
Green
MR Capsules 90mg, 120mg, 180mg

Prescribe by brand 
   
Diltiazem Hydrochloride (Dilzem® SR)
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Formulary
Green
MR Capsules (SR) 60mg
(twice daily dosing)

Prescribe by brand 
   
Nifedipine
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Formulary
Green
Capsules 5mg, 10mg 
   
Nifedipine (Adalat® LA)
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Formulary
Green
MR tablets 20mg, 30mg, 60mg
(once daily dosing)

Prescribe by brand 
   
Nifedipine (Adalat® Retard)
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Formulary
Green
MR tablets 10mg, 20mg
(twice daily dosing)

Prescribe by brand 
   
Nifedipine (Coracten® SR)
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Formulary
Green
MR capsules 10mg
(twice daily dosing)

Prescribe by brand 
   
Verapamil Hydrochloride
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Formulary
Green
Tablets 40mg, 80mg, 120mg;
Injection 5mg/2ml (hospital only) 
   
02.06.03  Other anitanginal drugs
Nicorandil (Ikorel®)
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Restricted Drug Restricted
Amber
 
Link  Nicorandil (Ikorel): now second-line treatment for angina - risk of ulcer complications
   
Ranolazine (Ranexa®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
  • Consider ranolazine as monotherapy for stable angina if beta blockers and calcium channel blockers cannot be tolerated or both are contraindicated.
  • Consider adding ranolazine if symptoms of stable angina are not controlled with beta blocker or calcium channel blocker monotherapy and the other option (calcium channel blocker or beta blocker) is contraindicated or not tolerated.

See NICE CG126: stable angina
 

 

 
Link  NICE CG126: Stable angina
   
Ivabradine (Procoralan®)
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Restricted Drug Restricted
Amber

 
For use by Cardiologists only.

  • for angina in line with NICE CG126
  • for heart failure in line with NICE TA267 
 
Link  NICE CG126: Stable angina
Link  NICE TA267: Ivabradine for treating chronic heart failure
   
02.06.04  Peripheral vasodilators and related drugs
Naftidrofuryl Oxalate
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Formulary
Green
Formulary as per NICE TA223 
   
Pentoxifylline (Trental®)
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Unlicensed Drug Unlicensed
Green
 
   
02.06.04  Other preparations used in peripheral vascular disease
02.07  Sympathomimetics to top
Midodrine (Unlicensed)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Amber
Tablets 5mg

For use by specialists only 
   
02.07.01  Inotropic sympathomimetics
Dobutamine
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Formulary
Red
Injection 250mg/20ml 
   
Dopamine Hydrochloride
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Formulary
Red
Injection 200mg/5ml, 800mg/20ml 
   
Isoprenaline Sulphate (Unlicensed Medicine)
(2mg/2mL Injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
Stock kept on ITU only 
Link  HDFT Isoprenaline Protocol
   
02.07.02  Vasoconstrictor sympathomimetics
Ephedrine Hydrocloride
View adult BNF View SPC online View childrens BNF
Formulary
Red
Injection 30mg/ml; Pre-filled syringe 30mg/10ml 
   
Noradrenaline Acid Tartrate / Norepinephrine Bitartrate (Noradrenaline ®/ Norepinephrine)
View adult BNF View SPC online View childrens BNF
Formulary
Red
Injection 2mg/ml
(equivalent to noradrenaline base 1mg/ml) 
   
02.07.03  Cardiopulmonary resuscitation
Adrenaline / Epinephrine (Adrenaline / Epinephrine 1 in 10000, dilute)
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Formulary  
   
02.08  Anticoagulants and protamine
02.08.01  Parenteral anticoagulants to top
Argatroban (Exembol®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
 
Link  Guidelines for the Management of Heparin-Induced Thrombocytopenia (HIT)
   
02.08.01  Heparin
Unfractionated Heparin
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Formulary Sub-cutaneous injection 5000 units/0.2ml - for VTE prophylaxis if CrCl <10ml/min.

Injection 1000units/ml (20ml ampoules) - for use as an infusion (see individual charts).

Injection 50 units/5ml - For central lines and paediatric peripheral lines only.

Heparinised saline 1000 units/500ml
For use in cardiac unit only. 
Link  HDFT Unfractionated Heparin Chart (Lilac)
Link  Management of heparin induced thrombocytopenia (HIT) guidelines
   
02.08.01  Low molecular weight heparins
Tinzaparin Sodium
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First Choice
Amber
 
Enoxaparin Sodium (100mg in 1mL and 150mg in 1mL)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
Pre-filled syringe 20mg, 40mg, 60mg, 80mg, 100mg, 120mg, 150mg

For therapeutic dosing when CrCl is <30ml/min 
Link  Anti Xa Monitoring Flow Chart
Link  Switching Anticoagulant Guidance
   
02.08.01  Heparinoids
02.08.01  Hirudins
02.08.01  Heparin flushes to top
02.08.01  Epoprostenol
02.08.01  Fondaparinux
Fondaparinux Sodium (Arixtra®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
Pre-filled syringe 5mg/ml

For use in acute coronary syndromes 
Link  Fondaparinux Prescribing Guidelines
   
02.08.02  Oral anticoagulants
 note 

New Oral Anticoagulant (NOAC) clinical decision making tool

Peri-operative and post-operative management of patients taking new oral anticoagulants - guidelines

Warfarin Sodium
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First Choice
Green
 
Rivaroxaban (Xarelto®)
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First Choice
Green
As per NICE guidelines
 
Dabigatran (Pradaxa®)
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Formulary
Green
See NICE guidance.
NOAC of choice in patients requiring cardioversion.

Dabigatran and edoxaban will be reserved for those who have a contra-indication to, or intolerant of rivaroxaban / apixaban or where the prescriber feels dabigatran or edoxaban would be the most appropriate agent. 
Link  NICE TA 327: Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism
Link  NICE TA249: Dabigatran for the treatment and secondary prevention of stroke and systemic embolism in atrial fibrilation
Link  NOAC Clinical Decision Making Tool
Link  Switching Anticoagulant Guidance
   
Apixaban (Eliquis®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
See NICE guidance.

 
Link  NICE guidance: Apixaban for the prevention of VTE after total hip or knee replacement in adults
Link  NOAC Clinical Decision Making Tool
Link  Switching Anticoagulant Guidance
   
Edoxaban (Lixiana®)
(Tablets: 15mg, 30mg and 60mg)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
Dabigatran and edoxaban will be reserved for those who have a contra-indication to, or intolerant of rivaroxaban / apixaban or where the prescriber feels dabigatran or edoxaban would be the most appropriate agent. 
Link  NICE TA354: Edoxaban for treating and preventing DVT and PE
Link  NICE TA355: Edoxaban for preventing stroke and embolism in people with non-valvular AF
Link  Switching Anticoagulant Guidance
   
02.08.02  Stroke prevention in AF
02.08.02  VTE treatment to top
02.08.02  VTE prophylaxis in hip/knee surgery
02.08.03  Protamine sulphate
Protamine Sulphate
View adult BNF View SPC online View childrens BNF
Formulary
Red
Injection 10mg/ml 
   
02.09  Antiplatelet drugs
 note  Guidelines for perioperative management of patients taking antiplatelet drugs
Aspirin (antiplatelet) (Aspirin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
Dispersible tablets 75mg

Not to be used as monotherapy for atrial fibrilation

 
Link  VTE thromboprophylaxis in adult orthopaedic patients
   
Clopidogrel
View adult BNF View SPC online View childrens BNF
Formulary
Green
Tablets 75mg 
   
Dipyridamole (Persantin® Retard)
View adult BNF View SPC online View childrens BNF
Formulary
Green
MR capsules 200mg 
   
Dipyridamole and Aspirin (Asasantin® Retard)
View adult BNF View SPC online View childrens BNF
Formulary MR capsules aspirin/dipyridamole 25/200mg 
   
Eptifibatide (Integrilin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
Injection 20mg/10ml
Infusion 75mg/100ml 
Link  Eptifibatide Guidance for Patients with Aute Coronary Syndrome
   
Prasugrel (Efient®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Amber
Tablets 5mg, 10mg

For use by a specialist only 
   
Ticagrelor (Brilique®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Amber
60mg tablets
90mg tablets 
Link  Guidance on Extended Duration Ticagrelor Therapy following Myocardial Infarction
Link  HDFT Primary PCI Pathway
Link  NICE TA420: Ticagrelor for preventing atherothrombotic events after myocardial infarction
Link  Ticagrelor prescribing guidance for ACS - West Yorkshire Cardiovascular Network
   
Tirofiban (Aggrastat®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
 
Link  HDFT Tifofiban Protocol
   
02.10  Stable angina, acute coronary syndromes, and fibrinolysis
02.10.01  Management of stable angina and acute coronary syndromes to top
02.10.02  Fibrinolytic drugs
Alteplase (Actilyse®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
Injection 20mg, 50mg

For specialist use only 
Link  Alteplase Prescription Chart
   
Streptokinase
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
Injection 1.5million units

Intrapleural use for empyema 
   
Tenecteplase (Metalyse®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
Injection 8000units, 10000units

Use in accordance with thrombolysis protocol. 
   
Urokinase (Syner-KINASE®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
Injection 25000 units

For thrombosed intravascular catheters and cannulae & peripheral vascular occlusion 
   
02.11  Antifibrinolytic drugs and haemostatics
Tranexamic Acid
View adult BNF View SPC online View childrens BNF
Formulary
Green
Tablets 500mg; Injection 500mg/5ml 
   
02.11  Blood-related products
Fresh Frozen Plasma
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
Available from Haematology 
   
02.12  Lipid-regulating drugs
02.12  Statins to top
Simvastatin
View adult BNF View SPC online View childrens BNF
First Choice
Green
Tablets 20mg, 40mg 
Atorvastatin (Lipitor®)
View adult BNF View SPC online View childrens BNF
Second Choice
Green
Tablets 10mg, 20mg, 40mg, 80mg

Initiation by a specialist only.
Atorvastatin 80mg OD for use post ACS for 6 months then switch to simvastatin 40mg if target cholesterol achieved. 
Link  Lipid Modification Guidelines
   
Pravastatin Sodium
View adult BNF View SPC online View childrens BNF
Formulary
Green
Tablets 10mg, 20mg

Use if adverse effects with simvastatin 
   
Rosuvastatin (Crestor®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Green
Tablets 5mg, 10mg, 20mg

For use by Consultant Cardiologists only 
   
02.12  Bile acid sequestrants
Colesevelam ( Cholestagel®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Amber
management of bile acid malabsorption 
Link  NICE evidence review: Colesevelam for bile acid malabsorption
   
02.12  Ezetimibe
Ezetimibe (Ezetrol®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
Tablets 10mg

 
   
02.12  Fibrates
Fenofibrate
View adult BNF View SPC online View childrens BNF
Formulary
Green
Tablets 160mg 
   
02.12  Nicotinic acid group
02.12  Omega-3 fatty acid compounds to top
02.13  Local sclerosants
Ethanolamine Oleate
View adult BNF View SPC online View childrens BNF
Formulary
Red
Injection 5% 
   
02.14  Drugs affecting the ductus arteriosus
Alprostadil  (Prostin VR®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
Injection 500microgram/ml

For use in neonates only 
Link  Alprostadil in neonates - dosing and administration quick reference guide
Link  Yorkshire Neonatal Network and Yorkshire Paediatric Cardiology Network regional guidelines on use of Alprostadil in duct dependent congenital heart conditions in neonates
   
 ....
 Non Formulary Items
Abciximab  (ReoPro®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Acebutolol  (Sectral®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Acenocoumarol  (Sinthrome®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Acipimox  (Olbetam®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Amlodipine and Valsartan  (Exforge®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Antithrombin III  (Kybemin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Aprotinin  (Trasylol®)

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Non Formulary
 
Aspirin (antiplatelet)  (Nu-Seals® Aspirin)

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Non Formulary
 
Atenolol and Chlortalidone  (Co-tenidone®)

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Non Formulary
 
Atenolol and Chlortalidone  (Tenoret® 50)

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Non Formulary
 
Atenolol and Chlortalidone  (Tenoretic®)

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Non Formulary
 
Atenolol and Co-amilozide  (Kalten®)

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Non Formulary
 
Atenolol and Nifedipine  (Beta-Adalat®)

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Non Formulary
 
Atenolol and Nifedipine  (Tenif®)

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Non Formulary
 
Bemiparin Sodium

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Non Formulary
 
Bendroflumethiazide

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Non Formulary No longer recommended by NICE for management of hypertension
 
Bezafibrate

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Non Formulary
 
Bezafibrate  (Bezalip® Mono)

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Non Formulary
 
Bivalirudin  (Angiox®)

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Non Formulary
 
Bosentan  (Tracleer®)

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Non Formulary
 
Burinex K®

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Non Formulary
 
Canusal®

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Non Formulary
 
Captopril

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Non Formulary
 
Captopril and Hydrochlorothiazide  (Capozide®)

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Non Formulary
 
Captopril and Hydrochlorothiazide  (Co-zidocapt®)

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Non Formulary
 
Celiprolol Hydrochloride

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Non Formulary
 
Celiprolol Hydrochloride  (Celectol®)

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Non Formulary
 
Centyl K®

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Non Formulary
 
Cilostazol  (Pletal®)

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Non Formulary
 
Ciprofibrate  (Modalim®)

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Non Formulary
 
Clizazpril  (Vascace®)

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Non Formulary
 
Clonidine Hydrochloride  (Catapres®)

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Non Formulary
 
Clonidine Hydrochloride  (Dixarit®)

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Non Formulary
 
Co-amilozide

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Non Formulary
 
Co-flumactone

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Non Formulary
 
Colestripol Hydrochoride  (Colestid®)

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Non Formulary
 
Colestyramine

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Non Formulary
 
Colestyramine  (Questran® Light)

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Non Formulary
 
Co-triamterzide

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Non Formulary
 
Cyclopenthiazide  (Navidrex®)

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Non Formulary
 
Dalteparin Sodium

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Non Formulary
Red
 
Danaparoid Sodium  (Orgaran®)

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Non Formulary
 
Diazoxide  (Eudemine®)

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Non Formulary
 
Digitoxin

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Non Formulary
 
Diltiazem Hydrochloride  (Angitil® SR)

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Non Formulary
 
Diltiazem Hydrochloride  (Angitil® XL)

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Non Formulary
 
Diltiazem Hydrochloride  (Calaiard® CR)

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Non Formulary
 
Diltiazem Hydrochloride  (Dilcardia® SR)

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Non Formulary
 
Diltiazem Hydrochloride  (Dilzem® XL)

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Non Formulary
 
Diltiazem Hydrochloride  (Slozem®)

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Non Formulary
 
Diltiazem Hydrochloride  (Tildem® LA)

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Non Formulary
 
Diltiazem Hydrochloride  (Tildem® Retard)

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Non Formulary
 
Diltiazem Hydrochloride  (Viazem® XL)

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Non Formulary
 
Diltiazem Hydrochloride  (Zemtard®)

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Non Formulary
 
Dipyridamole

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Non Formulary
 
Disopyramide  (Rythmodan®)

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Non Formulary
 
Disopyramide  (Rythmodan® Retard)

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Non Formulary
 
Diumide-K Continus®

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Non Formulary
 
Dopamine Hydrochloride  (Select-A-jet® Dopamine)

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Non Formulary
 
Dopexamine Hydrochloride  (Dopacard®)

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Non Formulary
 
Doxazosin  (Cardura® XL)

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Non Formulary
Black
MR Tablets 4mg, 8mg
 
Dyazide®

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Non Formulary
 
Enalapril Meleate

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Non Formulary
 
Enalapril Meleate and Hydrochlorothiazide  (Innozide®)

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Non Formulary
 
Enoximone  (Perfan®)

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Non Formulary
 
Epoprostenol  (Flolan®)

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Non Formulary
 
Etamsylate  (Dicynene®)

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Non Formulary
 
Factor IX Fraction, Dried

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Factor VIIa (Recombinant)  (Novo 7®)

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Non Formulary
 
Factor VIII Fraction, Dried

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Non Formulary
 
Factor VIII Inhibitor Bypassing Fraction

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Non Formulary
 
Factor XIII Fraction, Dried

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Non Formulary
 
Felodipine

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Non Formulary
 
Felodipine  (Plendil®)

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Non Formulary
 
Fenofibrate  (Supralip® 160)

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Non Formulary
 
Fluvastatin  (Lescol®)

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Non Formulary
 
Fluvastatin  (Lescol® XL)

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Non Formulary
 
Fosinopril Sodium

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Non Formulary
 
Fosinopril Sodium  (Staril®)

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Non Formulary
 
Frusene®

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Non Formulary
 
Gemifibrozil

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Non Formulary
 
Glyceryl Trinitrate  (Nitro-Dur®)

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Non Formulary
 
Glyceryl Trinitrate  (Transiderm-Nitro®)

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Non Formulary
 
Guanethidine Monosulphate  (Ismelin®)

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Non Formulary
 
Hepsal®

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Non Formulary
 
Hydrochlorothiazide

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Non Formulary
 
Iloprost

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Non Formulary
 
Iloprost  (Vantavis®)

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Non Formulary
 
Imidapril Hydrochloride  (Tanatril®)

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Non Formulary
 
Indapamide  (Natrilix-SR®)

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Non Formulary
 
Indoramin  (Baratol®)

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Non Formulary
 
Indoramin  (Doralese®)

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Non Formulary
 
Inositol Nicotinate  (Hexopal®)

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Non Formulary Tablets 500mg
 
Isosorbide Dinitrate  (Angitak®)

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Non Formulary
 
Isosorbide Dinitrate  (Codocard® Retard)

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Non Formulary
 
Isosorbide Dinitrate  (Isoket®)

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Non Formulary
 
Isosorbide Dinitrate  (Isoket® Retard)

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Non Formulary
 
Isradipine  (Prescal®)

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Non Formulary
 
Kalspare®

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Non Formulary
 
Labetalol Hydrochloride  (Trandate®)

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Non Formulary
 
Lacidipine  (Motens®)

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Non Formulary
 
Lasikal®

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Non Formulary
 
Lasilactone®

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Non Formulary
 
Lepirudin  (Refludan®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lercanidipine Hydrochloride  (Zanidip®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lisinopril and Hydrochlorothiazide  (Carace® Plus)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lisinopril and Hydrochlorothiazide  (Lisicostad®)

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Non Formulary
 
Lisinopril and Hydrochlorothiazide  (Zestoretic®)

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Non Formulary
 
Metaraminol

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Non Formulary
 
Methyldopa

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Non Formulary
 
Metoprolol Tartrate  (Betaloc-SA®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Metoprolol Tartrate  (Lopresor® SR)

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Non Formulary
 
Mexiletine Hydrochloride  (Mexitil®)

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Non Formulary
 
Milrinone  (Primacor®)

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Non Formulary
 
Minioxidil  (Loniten®)

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Non Formulary
 
Moexipril Hydrochloride  (Perdix®)

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Non Formulary
 
Moracizine

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Non Formulary
 
Moxisylyte  (Opilon®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nadolol  (Corgard®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Navispare®

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Neo-NaClex-K®

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nicardipine Hydrochloride  (Cardene®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nicardipine Hydrochloride  (Nicardipine®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nicotinic Acid  (Niaspan®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nifedipine  (Adipine® MR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nifedipine  (Adipine® XL)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nifedipine  (Cardilate® MR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nifedipine  (Cardilate® SR)

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Non Formulary
 
Nifedipine  (Fortipine® LA 40)

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Non Formulary
 
Nifedipine  (Hypolar® Retard 20)

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Non Formulary
 
Nifedipine  (Nifedipress® MR)

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Non Formulary
 
Nifedipine  (Nifopress® Retard)

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Non Formulary
 
Nifedipine  (Tensipine® MR)

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Non Formulary
 
Nimodipine  (Nimotop®)

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Non Formulary
 
Nisoldipine  (Syscor® MR)

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Non Formulary
 
Olmesartan Medoxomil  (Sevikar®)

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Non Formulary
 
Omega-3-Acid Ethyl Esters  (Omacor®)

View adult BNF View SPC online View childrens BNF
Non Formulary Removed from formulary November 2012. Refer to LPG minutes November 2012.
 
Omega-3-Marine Triglycerides  (Maxepa®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Oxerutins  (Paroven®)

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Non Formulary
 
Oxprenolol Hydrochloride

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Oxprenolol Hydrochloride  (Slow-Trasicor®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Oxprenolol Hydrochloride  (Trasicor®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Oxprenolol Hydrochloride and Cyclopenthiazide  (Trasidrex®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Perindopril Erbumine and Indapamide  (Coversyl® plus)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Phenindione

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Phenoxybenzamine Hydrochloride

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Phenoxybenzamine Hydrochloride  (Dibenyline®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Phentolamine Messilate  (Rogitine®)

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Non Formulary
 
Phenylephrine Hydrochloride  (Phenylephrine®)

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Non Formulary
 
Pindolol

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Pindolol  (Visken®)

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Non Formulary
 
Pindolol and Clopamide  (Viskaldix®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Prazosin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Procainamide Hydrochloride  (Pronestyl®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Propafenone Hydrochloride  (Arthmol®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Propranolol Hydrochloride  (Inderal®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Protein C Concentrate  (Ceprotin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Quinapril

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Quinapril  (Accupro®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Quinapril and Hydrochlorothiazide  (Accuretic®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ramipril and Felodipine  (Triapin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Reteplase  (Rapilysin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sildenafil  (Revatio®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sildenafil  (Viagra®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Simvastatin and Ezetimibe  (Inegy®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sitaxentan Sodium  (Thelin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sodium Nitroprusside

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sodium Tetradecyl Sulphate  (Fibro-Vein®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Terazosin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Terazosin  (Hytin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Timolol Maleate  (Betim®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Timolol Maleate and Bendroflumethiazide  (Prestim®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Timolol Maleate and Co-amilozide  (Moducren®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Tolazoline

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Torasemide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Torasemide  (Torem®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Trandolapril  (Gopten®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Trandolapril and Verapamil  (Tarka®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Tranexamic Acid  (Cyklokapron®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Triamterene  (Dytac®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Verapamil Hydrochloride  (Cordilox®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Verapamil Hydrochloride  (Half Sucuron® SR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Verapamil Hydrochloride  (Sucuron® SR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Verapamil Hydrochloride  (Univer®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Verapamil Hydrochloride  (Verapress® MR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Verapamil Hydrochloride  (Vertab® SR 240)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Amber

Medicines which are suitable to be prescribed in primary care only after specialist recommendation. Ongoing prescribing by primary care includes titration of dose and assessment of efficacy. There is no need for ongoing monitoring other than for general adverse effects as listed in the BNF & SPC.  

Amber Shared Care

Medicines which are suitable to be prescribed in primary care only after specialist recommendation only under a shared care protocol once the patient has been stabilised. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must be approved by the Harrogate & Rurual District Area Prescribing Committee (HaRD APC).   

Black

Medicines which the Harrogate & Rural District Area Prescribing Committee (HaRD APC) has reviewed and does not recommend for use at present based on a review of clinical and/or cost effectiveness data.   

Green

Medicines suitable for routine use and can be prescribed within primary care within their licensed indication in accordance with nationally recognised formularies e.g. BNF, BNF for Children, Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing.  

Grey

Medicines which the Harrogate & Rural District Area Prescribing Committee (HaRD APC) have not yet reviewed.   

Red

Medicines for hospital use only. The responsibility for initiation and monitoring treatment should rest with an appropriate hospital clinician. The drug should be supplied by the hospital for the duration of the treatment course. Primary care prescriber initiation or continuation of treatemnt is not recommended.  

netFormulary